hi Kevin,
I have tried to breed a Miniature (12") Poodle to my 18" Labradoodle for a smaller F1b Labradoodle. The first time the semen wasn't shipped properly, thanks to US Customs, from another breeder, and the second time it didn't take between my own Mini and Doodle.
I have never read of, nor have I heard of any adverse results to the PUPPIES from an Artificial Insemination, altho for the breeder there is a risk of the AI process not being succesful, as well as costly with no results. That seems to be an (understandable) factor in the higher cost of the Miniature Labradoodles.
My experience and limited observation is that the more diverse the size difference, the more liklihood of proportional issues on the Puppies. That might not be the case for all breeders or dogs, but that is my concern, and why I have chosen a fairly small standard Doodle to breed with an average Miniature. If I could have found a 14" Miniature I would have used him, or purchased him!
I hope this helps