I would just get them eating as soon as you can I've started at 3 weeks before on huge litters also, usually smaller litters are fine and mom keeps up with them. I did have a Lab that started losing her hair I freaked I had never had that happen, I heard about it but never seen it. I took her to the Vet and all they check for skin problems it ending up being the stress of the litter she was a small female 50 lbs and had 12 pups. She did get her hair back but imagine how bad she looked when people came to meet her and the pups. :shock: :shock: